Starc struck first in the fifth over to remove Azhar Ali for five when the opener edged a lead-footed drive to the slips where Usman Khawaja dived forward and to his left to take a fine, low catch.
However, things went pear shaped for Pakistan when they came out to bat and were blown away by the Australian pace attack under lights.
A total of 15 wickets fell on Friday after Australia resumed the second day at 288/3. After two days, the match appears to be going with traditional form. Under the lights, Pakistan nosedived showcasing little fortitude to capitulate against sustained Australian bowling. Pakistan went into the dinner break on 20 for 1, and for a while Babar Azam (19) and Sami Aslam (22) - the only men apart from Sarfraz to hit double figures - seemed like they would steady the ship. Next ball, veteran batsman Younis Khan was caught behind but Hazelwood was denied a hat- trick by the stout blade of captain Misbah-ul- Haq. "I think tomorrow is about getting those first two wickets as quickly and cheaply as we can".
Young opener Renshaw, who like Handscomb is playing only his second Test, repaid the faith put in him by the selectors with an impressive 71 on his home ground as Australia took the upper hand after Smith won the toss in the day-night Test.
Here's the evidence that would have ended Steve Smith's day.
Smith squandered his third life by slashing at a fuller delivery from paceman Wahab Riaz in the next over to be caught behind after adding only more run.
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Smith's dismissal triggered a spiral out of nowhere and, worryingly, a familiar collapse as Australia lost 6 for 67.
That brought Nic Maddinson, coming off a duck on debut, to the crease, but his stay was as brief as it was uncomfortable before he too edged Wahab into Sarfraz's gloves for just 1.
Maddinson should have been dismissed third ball without scoring if it weren't for the slippery fingers of Azhar. Showcasing maturity beyond his years, the 25-year-old broke the shackles in an attempt for his maiden Test century with a towering six off Yasir Shah to move to 97 late in the first session. On resumption, Australia lost wickets in consecutive deliveries, including Handscomb who played on to Wahab.
A 49-run last wicket partnership between Jackson Bird and Nathan Lyon changed the day. Much to the delight of an increasingly rabid crowd, the tailenders swung lustily to great effect and a healthy dose of luck to frustrate the tourists.
The Australian fielding was nearly flawless, with Khawaja at third slip, Smith at second and Matt Renshaw at first holding some sharp catches, a contrast to the error-riddled fielding performance from the Pakistan lineup which put down at least three regulation chances - two against Smith.