"While I share numerous concerns of Senator Murkowski, after meeting with Mrs. DeVos, she committed to me that she will work with all Alaskans to strengthen education throughout the state, in both public and private schools", Sullivan said.
Given the 52-48 GOP Senate majority, Republicans can afford to lose only two of their own if Democrats are united against DeVos. So far, only one Republican has voted against a cabinet nominee submitted by the new president - Kentucky Senator Rand Paul, who voted against new CIA Director Mike Pompeo's nomination.
White House press secretary Sean Spicer said of DeVos' pending confirmation, "I am 100 percent confident she will be the next secretary of education".
Critics have said she is unqualified because of her lack of experience in public education and because of responses in her Senate committee hearing that appeared to reveal a lack of knowledge about education law and testing.
GOP Leaders Move to Shore Up Shaky DeVos Nomination
Grayson said she supported at least one idea proposed by Trump and DeVos: to give school districts greater control of education. The announcements by Collins and Murkowski means that DeVos could be defeated if a single additional Republican joins them.
Senator Lamar Alexander of Tennessee, the Republican chairman of the Health, Education, Labor, and Pensions Committee, praised DeVos as an "excellent" pick for the job. A vote to overturn the vote was rejected after Hatch showed up in the committee room to effectively confirm the vote.
"Her concentration on charter schools and vouchers however raised the question about whether or not she fully appreciates that the security of education's primary focus must be on helping states and communities... strengthen our public schools", Collins said. "I have a great deal of respect for Mrs. DeVos".
Sen. Deb Fischer, R-Neb., will vote for Betsy DeVos, President Donald Trump's nominee for education secretary. She is an unbelievably qualified educator and advocate for students, teachers, parents, " he said. She also faced increased scrutiny for her vast wealth - estimated in the billions - and the potential conflicts of interest that came with it. It remains to be seen whether any Democrats will break ranks and vote for DeVos. But Senate Democrats have repeatedly requested the vote be delayed so they can hold additional hearings with DeVos.
DeVos, a Republican megadonor and education advocate who has long pushed for charter schools and K-12 tuition - online curriculum provider - using public funds, has encountered criticism since Trump nominated her.