In recent times, Uber Technologies Inc. has been continuously suffering attrition from the senior management employee's resignation.
Currently, the ride-hailing company is in the process of recruiting a second-in-command who can work alongside Kalanick, the CEO who has turned Uber into one of Silicon Valley's most successful companies but who has also become a magnet for criticism because of the win-at-all-costs culture he has fostered.
The biggest flashpoint for the company came last month when a former Uber engineer, Susan Fowler, detailed in a blog post a number of instances of sexual harassment and gender bias at the company.
Rachel Holt, who manages Uber's operations in the United States and Canada, conceded that the firm had underinvested in the driver experience and that the firm was now "re-examining everything we do".
Ms Holt said drivers who had amassed a long history of trips would be treated differently to a newer driver. Kalanick didn't participate in Tuesday's call.
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"We're updating many customer support policies that were unintentionally stacked against drivers".
Rival services such as Lyft allow riders to use the app to tip drivers after a ride has completed - but Uber has so far rejected adding the option. "And I can no longer continue as president of the ride sharing business".
The company has hired former U.S. Attorney General Eric Holder to evaluate sexual harassment claims.
Uber wouldn't go into detail about the departure when we reached out, but did confirm it.
She said the atmosphere at the company had created a "cult of the individual".
Uber said that despite an "incredibly challenging" last two months, the company saw more growth in the first 10 weeks of 2017 than it did during the same period in 2016.