Paul Pogba put in another patchy performance for Manchester United in their Europa League game against FC Rostov at Old Trafford on Thursday night.
Ibrahimovic made a nuisance of himself again 15 minutes in, but he fired over when trying to beat Medvedev from an acute angle for a second time instead of teeing up Henrikh Mkhitaryan after racing on to Mata's pinpoint pass.
The second half didn't get off to a great start for the EFL Cup winners, with midfielder Paul Pogba substituted two minutes after the restart, pulling up with what looked like a hamstring injury.
Pogba has scored seven goals and provided five assists in 41 appearances over all competitions for United this season. "We have the same players in the last match plus Ibrahimovic returning for the Europa League".
Rostov know that due to the current aggregate score they will need to score in Manchester and there is a clear sense that their best chance of eliminating United would have been with a triumph in Russian Federation, where Ajax and Bayern Munich had already been beaten this season.
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The Frenchman was then followed off of the field by teammate Daley Blind who took a knock to the head and was replaced by Phil Jones.
United's breakthrough finally appeared after 70 minutes, however.
The same pattern resumed with the Reds in complete control of proceedings but Rostov nearly took a surprise lead when dangerman Sardar Azmoun struck a fierce effort from the edge of the box which Sergio Romero repelled before the keeper fielded another shot from Miha Mevlja. It took a little while in terms of match time, but Ibrahimovic was back to doing Ibrahimovic things in short order.
United will find out on Friday who they will play in the quarter-finals, with the draw taking place at 12:00 GMT.
Subs not used: De Gea (GK), Young, Carrick, Lingard, Rashford.