Dortmund hosted Hamburg on Tuesday and got a huge save from Roman Burki on American internationally Bobby Wood in the opening 10 minutes.
Although the game will be played at the Allianz Arena, Bayern are coming off of a rare home loss suffered earlier this week to Hoffenheim.
Lewandowski netted either side of half-time at the Allianz Arena to leave him with 26 league goals this season - one more than main rival Aubameyang who failed to find the net on Saturday.
Bayern Munich first-choice goalkeeper Manuel Neuer neglected to recuperate from his calf injury in time for the match, whereas Thomas Muller was additionally ruled out due to his ankle trouble.
Dortmund's hopes of getting back in the match happen to be quashed shortly following the restart whistle as it just took four minutes for Bayern Munich to reopen the two-goal lead.
"We want to win the match, to keep up the rhythm and create a good atmosphere before the match against Real, that's our goal, " David Alaba said on the club website.
Robert Lewandowski doubled the lead from a free-kick before Raphael Guerreiro reduced the deficit.
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The Bavarians got off to an explosive start and were 2-0 up after only 10 minutes with 34-year-old Ribery completing a dazzling move that wrongfooted the entire Dortmund defence twice in the fourth minute.
Dortmund now sit fourth in the Bundesliga table after Hoffenheim leapfrogged them with a 1-0 victory over Bayern last week.
But before the heavyweight clash in Munich, second-placed Leipzig reduced the gap at the top to seven points in a dramatic finale against Leverkusen.
But Forsberg staged one last run down the wing and found Poulsen, who slid in to score off the post deep in stoppage time to lift Leipzig to 58 points. They're one point behind third place Hoffenheim, but a comfortable nine points ahead of fifth place Freiburg.
Schalke 04 scored twice in each half to crush strugglers VfL Wolfsburg 4-1 to climb up to 10th on 37 points. "But after Arjen Robben's goal (for 3-1) we controlled the game".
Mainz are only outside the relegation places on goal difference after their 1-0 defeat at Freiburg, whose striker Nils Petersen scored the second-half victor off the bench.
Captain Lars Stindl scored the victor nine minutes from time for Gladbach after Cologne had twice come from behind to equalise.