Soundgarden frontman Chris Cornell has died suddenly at the age of 52, according to U.S. reports as the result of a suicide attempt.
Cornell and his band Soundgarden have covered the song before and they did it again to close out the show at Detroit's Fox Theater on Wednesday.
The Detroit medical examiner has since confirmed that the cause of his death has been determined as suicide by hanging. "They would like to thank his fans for their continuous love and loyalty and ask that their privacy be respected at this time".
News of Cornell's death prompted scores of tweets expressing sadness.
Cornell was one of the leading voices of the 1990s grunge movement originating out of Seattle, joining the likes of Nirvana, Pearl Jam and Alice In Chains.
The group hit its commercial peak with its breakout album, "Superunknown" in 1994, which was nominated for a Grammy Award for best rock album.
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The band released three albums in six years and also performed at an event billed as Cuba's first outdoor rock concert by an American band.
Hunter Burgan: Saddened by the news of Chris Cornell's passing.
A Seattle native, Cornell came to prominence in the grunge scene in the early '90s after forming Soundgarden in 1984.
The band split in 1997, but Cornell's success continued as a solo artist and with Audioslave, the supergroup he formed with Rage Against the Machine members Tom Morello, Tim Commerford, and Brad Wilk.
In 2015, Cornell proved that he can still hit the high notes easily. As with Soundgarden's mid-Nineties high point, the band's self-titled 2002 debut contained several hits - their moody "Like a Stone" went gold - and their follow-up, Out of Exile, went to Number One on Billboard on the strength of the multi-textured Number One single "Be Yourself".
In addition to his music, Cornell also became involved in philanthropy and started the Chris and Vicky Cornell Foundation to support children facing challenges, including homelessness, poverty, abuse and neglect.