However, there were nervous moments around the Santiago Bernabeu when Stefan Jovetic brought Sevilla back into the game after Nacho's quickly taken free-kick and Ronaldo's 400th goal for Madrid had given the hosts' a 2-0 half-time lead.
"Vigo? We'll face that game in the same way as this one".
Real would then be able to turn their attention to next month's Champions League final against Juventus with confidence sky high, but Zidane is determined not to look too far ahead.
"It is not easy to win LaLiga", Zidane added.
Barca are top of the table on goal difference (77-60) but Madrid have two games remaining to Barca's one.
Atletico Madrid sealed the third automatic Champions League spot despite only drawing 1-1 at Real Betis and Sevilla were guaranteed fourth spot and a play-off berth in Europe's elite competition after Villarreal were held at home to Deportivo La Coruna, who clinched survival.
"We wanted to have a strong run of form going into the last part of the season and we can not afford to lose a single game".
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Arizona right-hander Tom Wilhelmsen hit Pirates catcher Chris Stewart in the right leg with two outs in the ninth inning. Unbeaten Dallas Keuchel (6-0) became the first six-game victor in the majors, helped by a home run from Carlos Correa.
Ronaldo, Real's all-time record goalscorer, slotted into an empty net in the 23rd minute after visiting goalkeeper Sergio Rico had parried a shot to reach another milestone for the Spanish giants - in just his 391st appearance.
"Mathematically we still have a chance", said defender Nico Pareja. We have to continue doing the same thing. It was a deserved victory, we started the game very well.
But Real have a game in hand and need four points from their final two matches to lift their first title since 2012.
Casemiro had replaced Colombian playmaker James Rodriguez, who took his time leaving the pitch, leading to a question over whether this had been a goodbye to the Bernabeu from a player linked with a big money summer move to Manchester United.
Simeone continued: "We will miss two games in the season, a shame, because they are the two most attractive, the Cup and Champions finals".
"I do not want to talk about anything else".
Nacho's goal was hotly disputed, though, with furious Sevilla players - who had no time to build a defensive wall or get organised - surrounding the referee in protest. "It's something that a forward of midfielder would do, so for Nacho to do is makes me happy for him".