The top-seeded Serb defeated Monfils, who reached his first grass-court final in 13 years, 6-3, 6-4 in an hour and 16 minutes, reports Efe.
The three-time Wimbledon champion got off to a dream start in his 98th career final, as he broke Monfils' serve to get an immediate break by virtue of a double fault from the second seed's racquet.
The 12-time Grand Slam victor was crowned champion at Devonshire Park after he beat Frenchman Gael Monfils 6-3 6-4 in front of a capacity crowd on centre court.
A positive Djokovic charged to the net to volley a victor for a hold in the opening game of the second set after Monfils had his first two break points of the match.
Djokovic has now won 19 consecutive matches against French players and 56 of 57 dating back to the 2010 Davis Cup final.
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World No. 2 Novak Djokovic has made his way into the final of the Aegon International, following a straight sets victory over Daniil Medvedev of Russian Federation.
"It was a great buildup, and hopefully I'll be able to take the confidence from here, good level of performance, into London".
Djokovic said earlier this week that 2017 had been his toughest year in tennis. "This is the kind of match situations that I was looking forward to having, and I'm glad it happened today and I managed to overcome that".
"But most of all, I felt very welcomed here by the people".
Monfils, meanwhile, opens up his Wimbledon campaign against a qualifier, Daniel Brands of Germany, and could well meet Djokovic again if the pair both advance to the fourth round. "Playing at Wimbledon and playing at any other tournament, as a matter of fact, gives me a lot of joy, and I think that's the key".
Djokovic told Eurosport: "First of all, he's my very good friend..."
"Obviously in the first set he served very good".