In an effort to keep the playing field level for Destiny 2 on PC, support for third-party streaming and game capture applications will be limited.
Considering the popularity of a lot of these applications - Discord is the preferred socializing application for PC gaming, MSI Afterburner is often used for framerate tests, and video capture is indeed integral to the large PC streaming community - this is unlikely to go down well with a lot of PC gamers.
One of the reasons why Activision is so optimistic about Destiny 2 is because it is taking steps to broaden the franchise's appeal, Hirshberg said, with things like bringing it to PC, localising it for more countries, and partnering with Blizzard to launch the PC edition through the World of Warcraft company's massively popular Battle.net service. Bungie also notes that both AMD ReLive and NVIDIA Shadowplay are supported. The content that the PC players will have for Destiny 2 has also been revealed and it is going to be quite the experience.
Other game capture programs, like Razer Cortex, Fraps and Dxtory have similar limitations. Windowed Mode/Borderless Fullscreen does not have these restrictions, and you can use OBS and XSplit here instead.
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This is explicitly because Bungie doesn't want third-party interference in the games.
Overlays Some features from third-party applications which rely on the use of screen overlays are generally not compatible with Destiny 2. This includes borderless fullscreen, so even though these rules are inconvenient, the fact that you still run the game in borderless fullscreen and stream it is nice. The main issue that is causing the incompatibility comes from any application on PC that attempts to insert code into the game client.
While the increased emphasis on story is sure to excite plenty of people, Destiny 2 is, first and foremost, a multiplayer game and several of those elements will be available for testing during the beta.