The county says their government offices will not be open Monday, but will reopen Tuesday at 10 a.m.
Madison County Central School opened on Saturday as a shelter for residents needing somewhere to go.
The district is among the first to cancel schools ahead of the storm.
These closings affect all students and staff in the Lexington Three attendance area and are also applicable to all after-school programs, scheduled athletic practices or games, and classes/events at the Lifelong Learning Center.
Several schools in our area will be closed on Monday due to the potential of severe weather associated with Hurricane Irma.
All Cherokee County schools will be closed on Monday.
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"Today, I am directing the closure of all public schools, state colleges, state universities and state offices for their normal activities effective Friday through Monday, to ensure we have every space available for sheltering and staging", Gov. Scott said.
Phillip Milano, JU News Director, sent a statement, which reads in part, "The campus is being fully prepared around the clock in the event of inclement weather from Irma".
Florida SouthWestern State College will be closed through Wednesday.
University of Florida in Gainesville said it's expecting to know more later on Tuesday, but has not yet gotten back to News4Jax with details.
The University of Central Florida was also looking at a number of possibilities on Tuesday.
Nova Southeastern University said all classes will be canceled, effective at 8 a.m. Wednesday.