According to the results of the League of Nations will determine the four participants of the final stage of Euro 2020 among those teams that failed to qualify for the European championship through traditional qualifications.
That means missing out on the potential for games against Germany, Italy, Spain and England, who are among the dozen teams to qualify for League A.
There will still be dates in the calendar for the top nations to play global friendlies, with Nations League games taking up four of the six available worldwide match dates at the end of next year.
The top four-ranked teams that do not qualify for Euro 2020 will contest a play-off in March 2020, with one finals place on offer.
The competition, which will begin in September 2018 and will create four qualifying places for Euro 2020.
The winners of the four groups in League A will play each other in a one-leg semi-final in June 2019, with the winners going forward to contest the final.
League B: Austria, Wales, Russia, Slovakia, Sweden, Ukraine, Republic of Ireland, Bosnia and Herzegovina, Northern Ireland, Denmark, Czech Republic, Turkey.
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The draw of the League of Nations on 24 January 2018 in Lausanne.
Teams will be split into four groups of three.
Play-offs in four separate one-off mini-tournaments will find the four final participants in the competition.
The third pot consists of Montenegro, Israel, Bulgaria and Finland, while the final pot has just three sides - Cyprus, Estonia and Lithuania. However, if a whole league does not have enough teams for a play-off, which is conceivable in League A, then the places will be filled by the best-ranked teams from the league below.
Uefa says teams in three-sided groups will play on four of the six matchdays.
Each league will have its own play-off competition with single-leg semi-final and final to decide who gets the final four places.
League D: Azerbaijan, Macedonia, Belarus, Georgia, Armenia, Latvia, Faroe Islands, Luxembourg, Kazakhstan, Moldova, Liechtenstein, Malta, Andorra, Kosovo, San Marino, Gibraltar.
The Uefa Nations League group stage will be played across three worldwide breaks between September and November 2018.