The blaze, dubbed the Creek Fire, was reported at 3:42 a.m.in the area of Gold Creek and Little Tujunga roads, according to the Los Angeles County Fire Department, which was assisting the U.S. Forest Service and the Los Angeles Fire Department in the battle.
More than 125 firefighters and helicopters dropping water were on the scene of the 405 freeway near the Getty Center, an art complex that draws almost 2 million visitors annually.
The blaze comes amid a red flag warning - due to low humidity and fierce Santa Ana winds - that is expected to last through much of the week. Both were closed for the day, as was Santa Monica College and all schools in the Santa Monica-Malibu school district.
Two firefighters were injured, officials said. About 700 firefighters responded to what was labeled the Creek Fire.
No injuries were reported as of 8 a.m. Fire officials said "multiple structures, " including homes, are threatened.
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"It's been years since anything here has burned at all", Los Angeles Fire Department Capt. Cody Weireter told The Times. The La Tuna Fire in September also sent massive amounts of smoke into the air above Los Angeles and forced the evacuation of hundreds of homes.
The fire was zero percent contained as of Wednesday morning, Terrazas said.
The weather conditions were impeding efforts to contain and extinguish the out-of-control blaze, as strong, gusty winds fueled the "extreme" fire behavior, according to the inciweb incident information website. Helicopters on sight. Evacuation centers set up at rec centers. All North Bound lanes of the 405 are closed in the area.
"Driving to LAX just as they're closing the 405 for this roaring hillside fire near the Getty exit", Rebecca Keegan, the Vanity Fair correspondent tweeted Wednesday. Winds were about 15 miles per hour.
The Los Angeles Police Department ordered mandatory evacuations and the California Department of Transportation closed Intereste 405 between Highway 101 and Interstate 10.